A new report in JAMA Internal Medicine reports a correlation of viagra (sildenafil) with an increased risk of melanoma, by up to 84% (news article here). The study looked at 26,000 men and found a correlation with melanoma, however no causation can be interpreted from the data (see my earlier post on causation and correlation). The authors state the obvious, that more research must be done to test the safety of viagra given these results. For those people with erectile dysfunction, the study emphasized that erectile dysfunction itself did not correlate with melanoma… phew.
“Sildenafil (viagra) use may be associated with an increased risk of developing melanoma. Although this study is insufficient to alter clinical recommendations, we support a need for continued investigation of this association.“
Another post from the 50th meeting of the American Society of Clinical Oncology (ASCO)(earlier post). Extremely promising results were shown for a new combination immunotherapy for melanoma (ipilimumab (Yervoy, Bristol-Myers Squibb), investigational antibody nivolumab (Bristol-Myers Squibb)). Melanoma has been a tricky, hard to treat cancer for researchers, so this small study is truly remarkable.
“Concurrent use of the 2 immune-checkpoint blockade agents has produced the “unprecedented” overall survival rates for metastatic melanoma of 85% at 1 year and 79% at 2 years in a phase 1 study, said lead author Mario Sznol, MD, from the Yale University School of Medicine in New Haven, Connecticut.
The median overall survival for the 53 patients treated in the study was 40 months — also unprecedented. “That’s amazing,” Dr. Sznol told Medscape Medical News.”
Medscape article here.
Summary and more findings.