If you have not read Lisa Genova’s book Still Alice, I highly recommend that you do. Especially if you are interested in neuroscience and neurodegenerative disease. The book, which captures Alzheimer’s Disease in a unique personal light, has now been made into a movie. I am very excited to see it, and I absolutely love Julianne Moore. I will post an update once I see it! Also check out this terrific article about the movie, the story, and more at The Conversation!
Still Alice Official Trailer #1 (2015) – Julianne Moore, Kate Bosworth Drama HD
Alice Howland, happily married with three grown children, is a renowned linguistics professor who starts to forget words. When she receives a devastating diagnosis, Alice and her family find their bonds tested.
An awesome new study published in Science Translational Medicine shows that a two-sided antibody could be an effective therapeutic for Alzheimers Disease. The brains of Alzheimers patients are riddled with pathological protein plaques and tangles. Removing the pathological protein from the brain using antibodies targeting them for degradation has long been thought to be a potential therapeutic. One major hurdle in implementing this, has been a mechanism to get the antibody into the brain. The brain is protected from the rest of the body by the blood brain barrier, making it harder to target with drugs and other large therapeutic agents. In this study, the authors have designed a two-sided antibody that can pass into the brain. One side of the antibody targets a protein in the brain that is responsible for making pathological amyloid. The other side of the antibody highjacks a receptor protein, which allows the antibody to enter the brain! The study shows that this antibody can be delivered intravenously in monkeys and reduce pathological protein in the brain!