A new connection between asthma and T cells in the immune system!! Props to my twin brother – one of the authors, and the featured scientist in the NIH video below! More info from the NIAID here – paper in Science Translational Medicine here, and featured summary – T cell types that take your breath away.
A new study has shown that targeting two immune cells—Th2 and Th17—and their downstream, inflammatory effects is better than targeting just one pathway in the context of asthma. The researchers also show that blocking the Th2 pathway, which is a target of commonly-prescribed corticosteroid drugs, may unexpectedly boost conditions for Th17-driven inflammation. These results clarify how immune cells and their products contribute to asthma, and the work may enable researchers to design and test therapies that target both pathways. The study appears in the August 19, 2015, edition of Science Translational Medicine and included scientists from NIAID, the University of Leicester, and Genentech.